Stanley T. Crooke's Antisense Drug Technology: Principles, Strategies, and PDF

By Stanley T. Crooke

ISBN-10: 0824705661

ISBN-13: 9780824705664

commonly revised and up-to-date, Antisense Drug expertise: ideas, options, and functions, moment Edition displays the logarithmic growth made long ago 4 years of oligonucleotide-based remedies, and, specifically, antisense therapeutics and examine. analyzing classes realized from the scientific trials of first new release medications, the booklet evaluates the expertise as a complete and provides new instructions and avenues of analysis and improvement.

Divided into 5 elements, the e-book starts with a radical creation to the mechanism of antisense drug motion together with the RNase H mechanism, small RNA silencing pathways, and the capability therapeutics of splice switching oligonucleotides. top researchers reveal the fundamentals of oligonucleotide therapeutics partly through delineating medicinal chemistry, pharmacokinetics, and supply routes comparable to liposomal formulations for nucleic acid delivery.  half 3 info hybridization established medicines and considers the dramatic advances represented through 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA medications. different chemical periods of substances and mechanisms of motion are defined partially 4 with additional discussions on enhancing the second one new release antisense medicines. the ultimate half delves deeply into healing purposes. Contributing authors study the potential for antisense medicinal drugs for the relief of cardiovascular ailments, metabolic ailments, inflammatory illnesses, melanoma, neurological issues, and immune modulation.

Presenting a hugely certain, lucid dialogue of the awesome advances within the box, Antisense Drug expertise: rules, options, and functions, moment Edition offers the platform for researchers to proceed to aggressively pursue the good chance represented by way of this intriguing technology.

--This textual content refers back to the Hardcover edition.

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Antisense Drug Technology: Principles, Strategies, and Applications: Principles, Strategies and Applications by Stanley T. Crooke

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